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96 (95% CI, 0.92-1.0. The correlation coefficient between ETCO2 and serum bicarbonate (HCO3) was 0.436 (P less then .001) and the correlation coefficient between ETCO2 and anion gap was -0.397 (P less then .001). CONCLUSION Among patients with hyperglycemia, prehospital levels of ETCO2 were significantly lower in patients with DKA compared to those without and were predictive of the diagnosis of DKA. Furthermore, out-of-hospital ETCO2 was significantly correlated with measures of metabolic acidosis.BACKGROUND Macitentan is an orally active, potent, dual e