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Hepatocellular carcinoma (HCC) is one of the most common and serious types of cancer in the world. Currently, the treatment options for patients with HCC are limited. Lipid metabolic alterations are being recognized as a therapeutic target in the past few years. De novo lipogenesis has been frequently observed in HCC. Fatty acid synthase (FASN) is the key enzyme of de novo lipogenesis. Previous studies have indicated that loss of FASN suppresses the growth of HCC cells, but it cannot completely prevent HCC formation in vivo. Thus, other m

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How to Prepare an Opening to Replace Bifold Doors If you're planning to replace your bifold doors, it's important to choose the right ones. Make sure they're properly sealed and weatherproofed to stop water infiltration, air leaks and lower temperatures inside. To ensure an easy installation, get a partner to assist. The kit should be approximately 1/8 inch narrower than the frame opening, and between 1 and 2 i