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Many eukaryotes assemble an actin- and myosin-based cytokinetic ring (CR) on the plasma membrane (PM) for cell division, but how it is anchored there remains unclear. In Schizosaccharomyces pombe, the F-BAR protein Cdc15 links the PM via its F-BAR domain to proteins in the CR's interior via its SH3 domain. However, Cdc15's F-BAR domain also directly binds formin Cdc12, suggesting that Cdc15 may polymerize a protein network directly adjacent to the membrane. Here, we determine that the F-BAR domain binds Cdc12 using residues on the face

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When it comes to home improvement, consider remodeling either your kitchen or bathroom first. are two of the best ways that you can add the most value to your house. If possible, add an additional bathroom to your house as this is always a way to boost the value of your home. Devote some time into weather-stripping your home. Even though your house might be insulated, there are probably small crevices around windows and doors through which air will leak. That means your house will lose cool air during the summer and warm air during the winter, leading to a