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24). The median overall survival (OS) was 14.2 and 11.5months in the S-IROX and mFFX groups (p = 0.34). There were no significant differences in the incidences of grade 3-4 adverse effects. The subgroup analyses suggested S-IROX demonstrated favorable OS in patients with PFS ≥6months of first-line gemcitabine plus nab-paclitaxel (p for interaction = 0.02). S-IROX and mFFX were similarly tolerable and effective as a second-line chemotherapy in patients with PC refractory to gemcitabine plus nab-paclitaxel. S-IROX and mFFX were

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yright © 2020 Cremers, Huizinga, Niessen, Krestin, Poot, Ikram, Lötjönen, Klein and Vernooij.The integrity of the frontal areas of the brain, specifically the prefrontal cortex, are critical to preserve cognition and mobility in late life. Prefrontal cortex regions are involved in executive functions and gait control and have been related to the performance of dual-tasks. Dual-task performance assessment may help identify older adults at risk of negative health outcomes. As an alternative to neuroimaging techniques that do not allow assessment during actual