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The effectiveness of Ustekinumab (UST) on Crohn's disease(CD)-associated spondyloarthropathy (SpA) is currently unknown. All consecutive CD patients with active SpA at the initiation of the treatment with UST were extracted from the cohort of the Sicilian Network for Inflammatory Bowel Diseases (SN-IBD). The primary outcome was the articular response at 8 and 24weeks, defined as the disappearance of objective signs of arthritis (swelling and/or articular stiffness) and resolution of pain. Thirty CD patients with active SpA at the

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Nonlinear finite element analysis was performed to determine areas of high strain in relation to ulcer formation. Scaffolds demonstrated precise anatomic appearance and maintenance of integrity of both anterior and posterior auricular surfaces and scaffold projection, with no statistically significant differences in complications noted between the single- and two-staged implantation. While minor superficial ulcers occurred most commonly at the lateral and superior helix coincident with finite element predictions of high skin strains, e