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The experimental group was given orexin A and compared with the control group. Expression of PRRT2 protein was significantly increased (P less then 0.05), ABCG1 protein expression was significantly decreased (P less then 0.05), StAR expression was significantly increased (P less then 0.05), and progesterone secretion was significantly increased (P less then 0.05). The results showed that orexin A promoted the expression of StAR by upregulating PRRT2 and downregulating ABCG1, therefore affecting secretion of progesterone. Gene expression