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In multivariate analysis fat mass and free testosterone were independent predictors of Δ Gox, Gnonox and Δ% FFA, whereas only fat mass predicted Δ Lox. In women with PCOS, regardless of their phenotypes, insulin-mediated substrate utilization is impaired. This phenomenon is greater in subjects with the classic phenotype. Free testosterone plays an independent role on insulin action abnormalities on glucose and lipid metabolism. In women with PCOS, regardless of their phenotypes, insulin-mediated substrate utilization is impaired. This ph

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Necroptosis, a form of programmed cell death, is characterized by the loss of membrane integrity and release of intracellular contents, the execution of which depends on the membrane-disrupting activity of the Mixed Lineage Kinase Domain-Like protein (MLKL) upon its phosphorylation. Here we found myofibers committed MLKL-dependent necroptosis after muscle injury. Either pharmacological inhibition of the necroptosis upstream kinase Receptor Interacting Protein Kinases 1 (RIPK1) or genetic ablation of MLKL expression in myof