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https://www.selleckchem.com/products/nx-2127.html
H9C2 cardiomyocytes were employed for in vitro studies. Results Echocardiographic, hemodynamic and histological data showed overt myocardial hypertrophy and worsened cardiac function in diabetic mice. Chronic diabetic milieu enhanced SUMOylation and impaired nuclear translocation of XBP1s. Intriguingly, U0126 treatment significantly ameliorated progression of DCM, and this protective effect was achieved through enriching XBP1s' nuclear accumulation. Mechanistically, U0126 inhibited XBP1s' phosphorylation on S348 and SUMOylation on K276

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An Instagram Viewer is an online tool, app, or platform that allows users to view Instagram profiles, photos, videos, stories, reels, or highlights without needing to log in to an Instagram account.

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