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Best Affordable Robot Vacuum This basic robot vacuum is a great option if you don't require smart features like mapping, no-go zones and a self emptying dust bin. It costs less than $300. at cleaning carpets with low piles and hard floors. It also removes pet hair and other litter. It makes use of random navigation and is not connected to your home Wi-F

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Systemic fungal infections pose a serious clinical problem. Treatment options are limited, and antifungal drug resistance is increasing. In addition, a substantial proportion of patients do not respond to therapy despite being infected with fungi that are susceptible to the drug. The discordance between overall treatment outcome and low levels of clinical resistance may be attributable to antifungal drug tolerance. In this Review, we define and distinguish resistance and tolerance and discuss the current understanding of the mol