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Purulent sputum was identified in 77 patients (68%). The patients with PA, when compared with those without it, presented with more severe disease, higher serum fibrinogen levels, and lower FVC%. In addition, purulent sputum and long-term azithromycin treatment were more common in those with PA. The multivariate regression analysis showed that the independent factors associated with PA were serum fibrinogen level 400 mg/dL (OR = 3.0; 95% CI 1.1-7.7) and purulent sputum (OR = 4.3; 95% CI 1.6-11.3). In our sample, the prevalenc