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Decreased CDKN1A expression at mRNA (p = 0.02) and protein levels (p = 0.02) were associated with short overall survival and were independent predictors of prognosis (p less then 0.01 and less then 0.05 respectively). CDKN1A expression status is a prognostic biomarker independent of tumor stage. CDKN1A immunohistochemistry may be used to identify chRCC patients at greater risk of disease progression.Background Physical exercise helps to maintain a healthy lifestyle and its practice is recommended for women during pregnancy as a means of

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