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Based on these different cerebellar profiles and their unique contribution to early disease stages, we propose a refined model of cerebellar contribution to early AD development.One major challenge in medical imaging analysis is the lack of label and annotation which usually requires medical knowledge and training. This issue is particularly serious in the brain image analysis such as the analysis of retinal vasculature, which directly reflects the vascular condition of Central Nervous System (CNS). In this paper, we present a novel s