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To assess the influence of multiple uses on the cyclic flexural fatigue and torsional resistance of Reciproc R25 (REC) instruments. 256 canals (2 for each mandibular molar) were prepared using Reciproc R25 instruments. A total of 96 25-mm-long Reciproc R25 instruments were divided in six groups (n=8) on the basis of different number of canal shaped new instruments (control group), 1, 2, 3, 4 or 6 canals shaped during simulated clinical use for other groups respectively. Sixteen files were used for each of the six groups (8 instruments

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tive goals. Further research on factorial structure of a pool of items derived from these operational definitions is warranted. Such a factorial structure could be used as an intermediate link between specific behavioral items and explanatory psychobiological, learning, and cognitive mechanisms.In recent years, deep learning as a state-of-the-art machine learning technique has made great success in histopathological image classification. However, most of deep learning approaches rely heavily on the substantial task-specific annotations,