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The Best Robot Vacuum Cleaner Vacuuming is a major cause of many lives However, robot vacuums make it a little more enjoyable. Modern models can also mop and climb (small) steps. Some have a small trash bin that they empty by themselves. Others can be controlled via apps for smartphones instead of a physical remote. Some have mapping features that assist in navigation. 1. Power With the suction power of 8,000Pa Our top pick for robot vacuums is durable enough to take on t

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Butyrylcholinesterase (BChE), a hydrolytic enzyme, is responsible for the termination of the action of acetylcholine besides acetylcholinesterase (AChE) in the synaptic cleft of the brain. The alteration in the enzyme level, in patients with the progression of Alzheimer's disease, makes it a therapeutic target. In the present study, we developed BChE inhibitors through scaffold hopping by exploring two previously reported compounds, i.e., 1,4-bis((4-chlorophenyl) sulfonyl)-3,6-diphenylpiperazine-2,5-dione and N-(2-chlorophenyl)-4-(phe