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Our findings highlight the importance of family studies in unraveling MODY's incomplete penetrance, and provide further support for the involvement of dysregulated necroptosis in human disease.Utidelone (UTD1), a novel microtubule stabilizing agent, is an epothilone B analogue which was produced by genetic engineering. UTD1 has exhibited broad antitumor activity in multiple solid tumors. However, its activity and mechanism in colorectal cancer (CRC) remain to be studied. In this study, UTD1 dramatically inhibited CRC cell proliferat

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In this paper, a radial basis neural network adaptive sliding mode controller (RBF-NN ASMC) for nonlinear electromechanical actuator systems is proposed. The radial basis function neural network (RBF-NN) control algorithm is used to compensate for the friction disturbance torque in the electromechanical actuator system. An adaptive law was used to adjust the weights of the neural network to achieve real-time compensation of friction. The sliding mode controller is designed to suppress the model uncertainty and external disturbance effect