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Inhibition of Poly(ADP-ribose) polymerase (PARP) is effective for breast cancer susceptibility genes 1 (BRCA1)-deficient breast cancers. Although hormones play critical roles on the occurrence as well as being used in conventional therapies of breast cancer, their impacts on PARP-targeted therapy have been poorly addressed. Here, we showed that addition of estrogen could enhance the cytotoxicity of PARP inhibitors on estrogen receptor (ER)-positive breast cancer cells, causing significant suppression of cell growth. Further analysis rev

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Bi-Fold Door Repair Bi-fold doors are a great option to connect indoor and outdoor spaces. They give you clear views and easy access to your garden or patio. In time, they could cause problems that will require repair of bi-fold doors. These issues are typically simple to fix and are inexpensive. Misalignment Over time, bifold doors could become damaged or misaligned due to wear and wear and tear. The doors may not be closing properly, the track could be sagging or hinges might be loosening and require tight