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We identified 47 cases of IRIS; TB-IRIS was the most common type. The incidence of IRIS within 6months of ART initiation was 9.4%, and there were no significant differences in baseline characteristics and incidence of IRIS between the matched groups. The risk factors for IRIS were pre-ART CD4 T-cell count (30cells/μL), higher pre-ART viral load (≥75000 copies/mL), and TB-OI. The incidence of IRIS was 9.4% in Korean HIV patients. The INSTI regimen was not related to IRIS occurrence. The incidence of IRIS was 9.4% in Korean HIV patients. The INST