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Our data help explain the origin of structurally aberrant centrioles and why centriole numerical and structural defects coexist in tumors. This is a work of the U.S. Government and is not subject to copyright protection in the United States. Foreign copyrights may apply.MOTIVATION Complex diseases are due to the dense interactions of many disease-associated factors that dysregulate genes that in turn form so-called disease modules, which have shown to be a powerful concept for understanding pathological mechanisms. There exist many disea