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https://www.selleckchem.com/pr....oducts/cbl0137-cbl-0
Abnormal methylation of imprinted genes is commonly observed in the embryos cloned by somatic cell nuclear transfer (SCNT) procedure and is one of the primary reasons for their abnormal development and high mortality. Primordial germ cell 7 (PGC7), a developmentally regulated gene highly expressed in primordial germ cells, maintains the methylation level of imprinted genes by reducing the levels of 5-hydroxy-methylcytosine(5hmC) and increasing the levels of 5-methylcytosine(5 mC) during embryonic development. In this study, we
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