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https://pdisignals.com/index.p....hp/an-abandoned-doub
SARS-CoV-2 causes the ACE2 internalization and getting rid of, leading to the inactivation of the ACE2/Ang (1-7)/Mas axis. Consequently, we hypothesize that two hits towards the RAS drives COVID-19 progression. In brief, the initial hit comes from chronic irritation activating the ACE/Ang II/AT1R axis, as well as the second arises from the COVID-19 disease inactivating the ACE2/Ang (1-7)/Mas axis. Furthermore, the two hits to the RAS may be the major cause for increased mortality in patients with