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Immunotherapy with checkpoint inhibition has shown potent antitumor activity in patients with microsatellite instability (MSI) metastatic cancer. Microsatellite stable (MSS) colorectal cancer has long been considered resistant to immunotherapy. In this review, we provide an overview of current progress on strategies to overcome the resistance to immunotherapy in MSS colorectal cancer. Emerging evidence suggest that combination of immune modulators such as regorafenib may improve the responsiveness of MSS colorectal can
Hi, I'm Monica Lea a professionally trained singer and pianist with a classical background and the ability to perform across a wide range of genres, from jazz classics to today’s pop favorites. I provide a variety of musical services, including solo performances at public venues, resorts, hotels, and churches, as well as entertainment for private parties, engagements, fine dining atmospheres, corporate events, live shows, studio sessions, weddings, and memorial services.