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These extracts with considerable antimycobacterial activity showed 50% cytotoxic concentration (CC5 ranging from 94 to 384 μg/mL. Thus, Cleistopholis patens and Cryptolepis sanguinolenta are primed for further studies and could afford novel drugs for the mitigation of buruli ulcer disease. Thus, Cleistopholis patens and Cryptolepis sanguinolenta are primed for further studies and could afford novel drugs for the mitigation of buruli ulcer disease. Paratuberculosis is an enteric disease caused by Mycobacterium avium sp. paratuberculo