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To evaluate the role of L-carnitine (LC) on fructose-induced oxidative stress in Holtzman rats. An experimental study was carried out during 56 days, in patients assigned to 4 groups control, control+LC, fructose and fructose+LC. Patients in the fructose group received treatment during 56 days, and those in the LC groups were treated during the last 28 days. Fructose was given on demand and LC was administered orally at a dose of 500 g/kg/24 h. Lipid peroxidation (MDA), superoxide dismutase activity, free LC and mitochondrial and post-mi