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Our results suggest that undifferentiated and osteogenically induced JPCs-seeded β-TCP constructs have actually a broad inhibitory impact on monocyte-derived DC maturation.Changes into the plasma metabolic profile were characterised in newly identified arthritis rheumatoid (RA) patients upon commencement of mainstream disease-modifying anti-rheumatic drug (cDMARD) treatment. Plasma samples collected in an early on RA randomised strategy study (NCT00920478)