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i-motifs are trusted in nanotechnology. In biological methods, i-motifs get excited about gene legislation as well as in control of genome integrity. In vivo, the i-motif forming sequences are topics of epigenetic alterations, especially 5-cytosine methylation. In flowers, natively happening methylation habits cause a complex community of C+.C, 5mC+.C and 5mC+.5mC base-pairs in the i-motif stem. The impact of complex methylation habits (CMPs) on i-motif formation tendency happens to be un