https://www.selleckchem.com/pr....oducts/pf-07220060.h
D-optimal designs for darunavir were then calculated in PopED and further evaluated in NONMEM through simulations. External validation confirmed model robustness and accuracy in most scenarios but also highlighted several limitations. The best one-, two-, and three-point sampling strategies were determined to be pre-dose (0h); 0 and 4h; and 1, 4, and 19h, respectively. A combination of samples at 0, 1, and 4h was comparable to the optimal three-point strategy. These could be used to reliably estimate individual pharmacokinetic param
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