https://www.selleckchem.com/pr....oducts/nocodazole.ht
For Strategy A, two variants in Dickkopf Wnt Signaling Pathway Inhibitor 4 (DKK4), a p.Cys63Tyr (B141621481, c.188GA) and a less common p.Ala18Val (B142620835, c.53CT) variant are suggested as two alleles influencing the Ticked phenotype. Bioinformatic and molecular modeling analysis suggests that these changes disrupt a key disulfide bond in the Dkk4 cysteine-rich domain 1 or Dkk4 signal peptide cleavage respectively. All coding variants were excluded as Ticked alleles using Strategy B.EuIII , TbIII , GdIII and YbIII complex
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