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37, 95%CI 0.22-0.62, p less then 0.05). In the control group of second malaria attacks, the difference between the two groups was not statistically significant (RD = 1.16, 95%CI 0.81-1.66, p less then 0.05); there was no significant difference in treatment failure during follow-up (RD = -0.01, 95%CI 0.04-0.03, p less then 0.05). There were also very few serious adverse events in both groups. ACTs showed good therapeutic effects in preventing gametocythemia but did not control the recrudescence rate and overall cure, which indicate