https://www.selleckchem.com/products/PLX-4032.html
The present study demonstrates how quantum chemical calculations can be used for rational design of novel PAHs and for fine tuning of their properties.In this study, we capitalized on our previously performed crystallographic fragment screen and developed the antitubulin small molecule Todalam with only two rounds of straightforward chemical synthesis. Todalam binds to a novel tubulin site, disrupts microtubule networks in cells, arrests cells in G2/M, induces cell death, and synergizes with vinblastine. The compound destabilizes micro
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