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All relevant randomized controlled tests using COL to treat patients with PO will be included. Two researchers will determine scientific studies, gather data and assess the risk of bias of every included study independently. Any various views between 2 researchers will be dealt with by a third specialist via conversation. Data analysis will undoubtedly be held on using RevMan 5.3 software. Outcomes This study will evaluate the effect and protection of COL when it comes to remedy f

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