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As large numbers of candidate drugs and vaccines for potential use in the Covid-19 pandemic are investigated, medicines regulators globally must now make urgent, informed, contextually risk-based decisions regarding clinical trials and marketing authorizations. They must do this with the flexibility demanded by the pandemic while maintaining their core risk assessment and public safety functions. We lay out the critical role of regulators in the current crisis and offer eight "pandemic best regulatory practices."Aims and objectives The p

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