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Cancer is a major public health issue and represents the second leading cause of death in women worldwide, as female reproductive-related neoplasms are the main cause of incidence and mortality. Female reproductive cancers have a close relationship to estrogens, the principal female sex steroid hormones. Estrogens exert their actions by the nuclear estrogen receptor alpha (ERα) and estrogen receptor beta (ERβ). ERα, and ERβ act as transcription factors mediating genomic effects. Besides, the G protein-coupled estrogen receptor (GPER, form

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Adult ADHD Signs and Symptoms Do you get distracted at work, struggle to complete tasks or miss appointments? If yes, you might be suffering from adult ADHD. These issues can affect your home, work and relationships. Your doctor will gather information from your family and school use checklists and rating scales to review your symptoms. 1. Inattentiveness Inattentive ADHD sufferers have difficulty paying attention to tasks and following instructions. They can forget important papers or fail to attend appointments. They tend to forget importa