https://www.selleckchem.com/pr....oducts/bay-1895344-h
We read with interest the recent paper published by Khusid et al (1), highlighting the effects of the COVID-19 pandemic on resident well-being and educational outcomes. We too have sensed the urgent need for adapting clinical, educational and scientific practice to appropriately attend to the public health crisis. As stated by the authors (1), significant changes have been reported in the structure of academic centers with an important impact on the daily practice of health professionals including resident physicians. Accordingl

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Reactive oxygen species (ROS) cause oxidative damage to proteins and generate deleterious by-products which induce a breakdown of immune tolerance and produce antibodies against host macromolecules with implication in human diseases. This study characterizes the hydroxyl radical (OH) modifications of insulin, evaluates its cytotoxicity and immunogenicity, and probes its role in type 2 diabetes (T2DM) autoimmunity. The results demonstrate susceptibility of insulin to modifications induced by OH, causing exposure of its chromophoric aroma