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inositol triphosphate receptor. Bile acids induce a sustained Ca2+ influx from the endoplasmic reticulum and release of Ca2+ from acidic stores into the cytosol of acinar cells. The overload of intracellular Ca2+ results in mitochondrial depolarization and subsequent acinar cell necrosis. In addition, BAs have a biphasic effect on pancreatic ductal cells. A more detailed characterization of the mechanisms through which BAs contribute to the disease pathogenesis and severity will greatly improve our understanding of the underlying pathop

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To encourage your cat to use the flap, begin by playing and feeding close to it. This will make them familiar with the sound of it closing and opening. You can also add the scent of your cat to the flap. Then, you can move the flap slightly to give your cat an impression of movement. Try to entice them by holding their favorite treat or toys. Certain plants (such as clary sage, cat germander, and valerian) are arousing scent that cats love. Installing the flap for cats A cat flap allows your cat to move aro