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We report on a 3-month-old female patient presenting with bilateral anonychia of the thumbnails and hyponychia of the index nails. Clinico-dermoscopic examination revealed triangular lunulae in all fingernails. Sequence analysis of LMX1B gene identified a novel heterozygous de novo mutation within exon 2, pathogenetic for a nail-patella syndrome. Multiple system atrophy (MSA) is a fatal neurodegenerative disease that belongs to the family of α-synucleinopathies. At post mortem examination, intracellular inclusions of misfolded α-synucle

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The amount of itraconazole in nail clippings was quantified hereafter using a validated HPLC method. RESULTS Statistical analysis showed that itraconazole transungual permeation was not influenced by the studied monoterpenes (P value .05). CONCLUSION These results provided a new perspective for designing topical dosage forms for the treatment of onychomycosis. © 2020 Wiley Periodicals, Inc.BACKGROUND/OBJECTIVES Despite the apparent efficacy and favorable toxicity profile of TKIs, allogeneic SCT remains the only curative treatment for CML espec