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Research on placebo analgesia commonly focuses on the impact of information about direction (i.e., increase or decrease of pain) and magnitude of the expected analgesic effect, whereas temporal aspects of expectations have received little attention so far. In a recent study, using short-lasting, low-intensity stimuli, we demonstrated that placebo analgesia onset is influenced by temporal information. Here, we investigate whether the same effect of temporal suggestions can be found in longer lasting, high-intensity pain in a Cold Pressor Test (CPT). Fifty-th

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ls of efficacy. • There is a wide variety in deployment strategies, pricing models, and CE marking class of AI products for radiology. • Interest in radiomics and machine learning is steadily increasing and is reflected both in research output and number of commercially available solutions.• Currently available commercial products using machine learning are often supported by limited evidence of clinical usefulness and studies are often of low methodological quality.• Ethical and regulatory issues remain open and hinder implementation o