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The ability of tumor cells to spread from their origin place and form secondary tumor foci is determined by the epithelial-mesenchymal transition process. In epithelial tumors such as prostate cancer (PCa), the loss of intercellular interactions can be observed as a change in expression of polarity proteins. Epithelial cells acquire ability to migrate, what leads to the formation of distal metastases. In recent years, the interest in miRNA molecules as potential future treatment options has increased. In tumor microenvironment, miRNAs h

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Only 4 patients felt small pain after a long-distance stroll, while another 6 patients showed small but acceptable disquiet in affected limbs. Five clients (11.6%) experienced osteomyelitis recurrence that needed secondary surgical and treatment, but no amputation was essential to get rid of the disease. Prolonged aseptic drainage was more frequent problem that was seen in 13 clients (30.0%). They certainly were successfully handled by proper wound caring in 10 customers and also by s