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For the prediction of allergy, both Lasso logistic regression and random forest were most informative with samples collected at 1month of age. A Lasso model with 27 proteins together with farm environment differentiated children who remained healthy from those developing allergy. This protein panel was primarily composed of antigen-presenting MHC class I molecules, interleukins and chemokines. Sampled at one month of age, circulating proteins that reflect processes of the immune system may predict the development of allergic disea