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To investigate the effectiveness of premixed insulin for achieving glycaemic outcomes in clinical practice in the UK. Electronic medical record data from The Health Improvement Network database were captured for adults with type 2 diabetes (T2D) uncontrolled (HbA1c ≥9%) on two or more oral antihyperglycaemic drugs (OADs) initiating premixed insulin. Effectiveness of premixed insulin was assessed by the probability and incidence of achieving glycaemic outcomes (target HbA1c 7.5% [58 mmol/mol] and a ≥1% or ≥2% HbA1c reduction) over