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Eighty-four patients (58.7%) were treated with 3D-CRT and 59 (41.3%) with IMRT. Adherence to the treatment protocol was high. The rate of grade ≥2 skin toxicity was 14.7% (95% confidence interval 9.8-21.4%). The most frequent grade3 toxicity (11%) was hot flashes. This study demonstrated low toxicity of and high treatment adherence to hypofractionated adjuvant radiotherapy with SIB in amulticenter prospective trial, although the primary hypothesis was not met. This study demonstrated low toxicity of and high treatment adherence to h