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Increased gene expressions of the apoptotic marker, caspase-3 and nuclear factor-kappa B (NF-K were observed in hepatic tissues of cisp la tin-treated rats. All these changes were further confirmed by histopathological findings in cisplatin group. Pre-treatment with betaine reduced serum aminotransferases (ALT and AST), and lowered hepatic concentrations of lipid peroxides, nitrite and TNF-a while increased SOD, GSH, catalase, and GSH-Px concentrations. Moreover, the histological and immunohisto-chemical changes