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In adhesion assays using recombinant host receptors, sickle-trait reduced adhesion by 73-86% to CD36 and 83% to EPCR. Similarly, sickle-trait reduced the surface expression of EPCR-binding PfEMP1. In conclusion, Sickle-cell trait does not directly affect var gene transcription but does reduce the surface expression and function of PfEMP1. This provides a direct mechanism for protection against severe malaria conferred by sickle-trait hemoglobin. Trial Registration ClinicalTrials.gov Identifier NCT02645604.Three months of weekly

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Buying Guide For Double Strollers If you have two children who are close in age A double stroller can be an invaluable investment. These compact tandem strollers or flexible side-by-side buggies let you keep an eye on both children at the same time while taking on the grocery store, parks and anything else life throws your way. Comfort Comfort is a major factor to consider when shopping for a double-stroller. This can include both the seating arrangement as well as the overall size of the stroller which can impact the ease of use and storage.