https://www.selleckchem.com/mTOR.html
The peptide receptor radionuclide therapy (PRRT) with 177Lu-DOTA-octreotate (LuTate) is recommended for different types of neuroendocrine tumors (NETs) which overexpress somatostatin receptors (SSTR). A combination with chemotherapy improves objective response to LuTate in NET patients and here we characterized chemotherapy-induced upregulation of SSTR2 receptors as a cause for this improved response to LuTate. The NET cell lines with low (BON-1) or relatively high (NCI-H727) SSTR2-expression levels, and non-NET cancer and normal cells were treated

https://www.selleckchem.com/pr....oducts/itacnosertib.
Single crystals of KScP2O7, potassium scandium diphosphate, were grown in a borate flux. The title compound crystallizes isotypically with KAlP2O7 in space-group type P21/c, Z = 4. The main building block is an ScP2O119- unit, forming layers parallel to (001). These layers are stacked along [001] via common corners of octa-hedral and tetra-hedral units to span up large hepta-gonal cavities that host the potassium cations with a coordination number of 10. The P-O-P bridging angle increases with increasing size of the octa-hedrally c