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No significant differences in QoL indices according to the type of treatment (conventional chemotherapy targeted therapy) were observed. CAEs, and particularly hand-foot toxicities, rashes, and papulopustular eruptions, can have an impact on QoL in outpatients receiving anticancer drugs as evaluated with three different patient-reported outcomes instruments. No differences in QoL related to CAEs were observed between conventional chemotherapy and targeted therapy. CAEs, and particularly hand-foot toxicities, rashes, and papulopustu