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0071). Male patients with a BMI of 25-30 kg/m (HR = 0.74, 95% CI 0.63-0.86) and 30-40 kg/m (HR = 0.63, 95% CI 0.53-0.76) had a significantly lower risk of 28-day mortality. A U-shaped association of BMI with 28-day mortality in critically ill sepsis patients was found, with the lowest 28-day mortality at a BMI range of 30-40 kg/m . Notably, male patients were protected by a higher BMI more effectively than female patients as males had a significantly lower mortality risk. A U-shaped association of BMI with 28-day mortality in