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Based on the gene correlation network, we identified the top 3 hub genes miR-181a-5p, POSTN, and CDH11. Among these, POSTN is a predicted target of miR-181a-5p and is supposed to work together with CDH11 as a functional group. Finally, we verified the expression pattern of the hub genes by in vitro quantification experiments in glucose-cultured HDFs. Our study suggested that miR-181a-5p possibly plays a key role in modulation of HDF behaviors during the diabetic state. However, the effects and mechanisms of miR-181a-5p in high glucose-cul

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Participants also self-reported hedonic wellbeing as well as self-care and precautionary behaviors, which formed the "responsible (health) behavior" factor. Structural equations model (n = 714 after list-wise deletion) showed that "resources," "challenges," and "enablers" form a second-order factor, "positive environments," and this factor strongly covaries with "responsible behavior" and "wellbeing." These results suggest that PEs are not only buffers against the negative impact of the COVID-19 pandemic but can also stimulate effect