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A waterborne exposure also reduced antioxidant gene expression; increased frequency of developmental abnormalities such as bent tails, jaw deformities and pericardial edema; and resulted in lower growth rates and hypoactivity. Overall, a waterborne exposure to PSNPs resulted in higher transfer to the brain and caused greater toxic effects to zebrafish compared to an injection exposure and highlights the key role of exposure routes in the uptake, localization and subsequent distribution of nanoparticles. BACKGROUND Tibi

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