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The ratio of actual to predicted yield demonstrated a high correlation coefficient (r=0.96) with linear regression and overall RMSE of 228.4, which was lower than the two prior studies (calculated RMSE=330.8 and 405.2). Subset analyses indicated male patients, lymphoma patients, and patients 60 years of age demonstrated lower RMSEs. We have demonstrated a simple yet robust formula that can be used prospectively to accurately predict the CD34+ stem cell yield in both autologous and allogeneic donors, which also accounts for recipient