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Logistic regression results show that increasing age, increasing RDW, and increasing CA153 can increase the risk of breast cancer. The area under the ROC (AUC) analysis showed that the combined specificity and sensitivity of the combined application of RDW, MPV, and CA153 for the identification of breast cancer is better than that of a single marker. The combined application of RDW, MPV, and CA153 can improve the differential diagnosis of breast cancer and breast hyperplasia. The combined application of RDW, MPV, and CA153 can impro