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The aim of optimization is to achieve the saving of maintenance time and reduce the negative environmental impact of winter maintenance by effectively deploying equipment and devices.Several anti-inflammatory agents based on pyrazole and imidazopyrazole scaffolds and a large library of substituted catechol PDE4D inhibitors were reported by us in the recent past. To obtain new molecules potentially able to act on different targets involved in inflammation onset we designed and synthesized a series of hybrid compounds by linking pyr